Essentially comical in tone, the film portrays members of a 'Blood Donation Club' and the dangerously beautiful vampire who crashes into their lives. A highly stylised mix of genres and techniques.
In a private high school, Maki, Niko, Kaoru, and Nami, four girls who are obsessed with blood donation, have started the Blood Donation Club, distancing themselves from the whole of the school environment, with the exception of the school nurse, Ms Chihiro, who is their closest "associate". One day, Maki meets Mai in the blood donation room, and is surprised to witness her rampage against the nurses before fainting. The girls eventually learn that her full name is Mai Vlad Transylvania. She is a dropout vampire who cannot attack humans, and is in desperate need of blood. Seems like a match made in heaven, with the girls deciding to provide their new friend with blood, most frequently their own.
"I sometimes feel aware of my age especially when I'm surrounded by staff that is much younger than me, or when I'm face to face with my daughter, who is no longer a child. Consequently, I've thought about these issues in my role as a filmmaker. I felt urged to give a message to the younger generation." (Mamoru Oshii)